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Biliary Cryptosporidiosis in HIV-infected People After the Waterborne Outbreak of Cryptosporidiosis in Milwaukee

Vakil, Nimish; Schwartz, Steven; Buggy, Brian, P.; et al.
New England Journal of Medicine (01/04/96) Vol 334, No.1, P. 19


In March 1993, a cryptosporidiosis outbreak occurred in Milwaukee, Wisc., when the municipal water supply was contaminated with cryptosporidium. Vakil et al. analyzed the clinical condition, CD4 cell count, and survival rate of a group of 82 HIV-infected patients who developed cryptosporidiosis during the outbreak. The authors report an increase, after the period of contamination, in the number of HIV-infected patients with cryptosporidiosis. One year after the outbreak, 17 percent of the patients with biliary symptoms and 52 percent of the patients without biliary symptoms had survived. Of the patients with biliary symptoms, 88 percent had CD4 counts less than 50, compared to 63 percent among those without biliary symptoms. The researchers concluded that HIV-infected patients with CD4 counts less than 50 per cubic millimeter who are exposed to cryptosporidium are at increased risk for biliary symptoms and for death within a year after that infection.


The CDC National Center for HIV, STD, and TB Prevention makes this information available as a public service only. Providing this information does not constitute endorsement by the CDC. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC National AIDS Clearinghouse should be cited as the source. Copyright 1996, Information, Inc., Bethesda, MD